FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

OYLER JOHN
2. Issuer Name and Ticker or Trading Symbol

BeiGene, Ltd. [ BGNE ]
5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chief Executive Officer
(Last)          (First)          (Middle)

C/O MOURANT GOVERNANCE SERVICES (CAYMAN), 94 SOLARIS AVENUE
3. Date of Earliest Transaction (MM/DD/YYYY)

9/14/2021
(Street)

CAMANA BAY, GRAND CAYMAN, E9 KY1-1108
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Ordinary Shares 9/14/2021  S(1)  157600 D$28.2175 (2)2267161 D  
Ordinary Shares 9/15/2021  S(1)  190203 D$29.3123 (3)1736904 D  
Ordinary Shares         545597 I See Footnote (4)
Ordinary Shares         7727927 I See Footnote (5)
Ordinary Shares         29439115 I See Footnote (6)
Ordinary Shares         10000000 I See Footnote (7)
Ordinary Shares         102188 I See Footnote (8)
American Depositary Shares 9/14/2021  S(1)  100 D$361.56 37777 D  
American Depositary Shares 9/14/2021  S(1)  700 D$362.8067 (9)37077 D  
American Depositary Shares 9/14/2021  S(1)  1400 D$364.2275 (10)35677 D  
American Depositary Shares 9/14/2021  S(1)  5657 D$365.6818 (11)30020 D  
American Depositary Shares 9/14/2021  S(1)  13072 D$366.4994 (12)16948 D  
American Depositary Shares 9/14/2021  S(1)  4759 D$367.5217 (13)12189 D  
American Depositary Shares 9/14/2021  S(1)  10989 D$368.505 (14)1200 D  
American Depositary Shares 9/14/2021  S(1)  1100 D$369.65 (15)100 D  
American Depositary Shares 9/14/2021  S(1)  100 D$370.48 0 D  
American Depositary Shares 9/15/2021  S(1)  6600 D$374.3874 (16)19558 D  
American Depositary Shares 9/15/2021  S(1)  3312 D$375.5985 (17)16246 D  
American Depositary Shares 9/15/2021  S(1)  3400 D$376.7723 (18)12846 D  
American Depositary Shares 9/15/2021  S(1)  4515 D$377.8775 (19)8331 D  
American Depositary Shares 9/15/2021  S(1)  5431 D$379.0161 (20)2900 D  
American Depositary Shares 9/15/2021  S(1)  2000 D$379.808 (21)900 D  
American Depositary Shares 9/15/2021  S(1)  700 D$382.055 (22)200 D  
American Depositary Shares 9/15/2021  S(1)  200 D$383 0 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares

Explanation of Responses:
(1) The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 5, 2020.
(2) The price reported in Column 4 is a weighted average price per ordinary share. One ordinary share equals 1/13 American Depositary Share. These shares were sold in multiple transactions at prices ranging from $27.6646 to $28.5902, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of ordinary shares sold at each separate price.
(3) The price reported in Column 4 is a weighted average price per ordinary share. One ordinary share equals 1/13 American Depositary Share. These shares were sold in multiple transactions at prices ranging from $28.6685 to $29.5684, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of ordinary shares sold at each separate price.
(4) These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.
(5) These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
(6) These securities are held by Oyler Investment LLC, of which 99% of the limited liability company interest is owned by a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
(7) These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.
(8) These securities are held by The John Oyler Legacy Trust, of which the Reporting Person's father is a trustee, for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership.
(9) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.75 to $362.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(10) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $364.00 to $364.84, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(11) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $365.02 to $366.01, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(12) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $366.02 to $367.01, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(13) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $367.03 to $368.02, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(14) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $368.05 to $369.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(15) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $369.30 to $370.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(16) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $374.00 to $374.995, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(17) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $375.02 to $376.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(18) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $376.15 to $377.03, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(19) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $377.29 to $378.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(20) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $378.52 to $379.42, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(21) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $379.54 to $380.08, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
(22) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $382.00 to $382.11, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
OYLER JOHN
C/O MOURANT GOVERNANCE SERVICES (CAYMAN)
94 SOLARIS AVENUE
CAMANA BAY, GRAND CAYMAN, E9 KY1-1108
X
Chief Executive Officer

Signatures
/s/ Qing Nian, as Attorney-in-Fact9/16/2021
**Signature of Reporting PersonDate


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.